An infant with recurrent nephrolithiasis in cystinuria despite urine alkalinization

Position Paper on urine alkalinization.

This Position Paper was prepared using the methodology agreed by the American Academy of Clinical Toxicology (AACT) and the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT). All relevant scientific literature was identified and reviewed critically by acknowledged experts using set criteria. Well-conducted clinical and experimental studies were given precedence over an...

Preventing recurrent nephrolithiasis in adults.

Necessity of fractionated urine collection for monitoring patients with cystinuria.

Cystinuria is an inherited form of nephrolithiasis caused by mutations in the SLC7A9 [solute carrier family 7 (cationic amino acid transporter, y system), member 9] and SLC3A1 [solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1] genes, which encode the luminal transporter b(0, ) AT subunit and ...

A young man presenting with recurrent nephrolithiasis

A male patient, born in 1990, first presented with a kidney stone when he was 10 years old, but the stone had passed spontaneously, and no further testing was done at that time. At the age of 20, he presented with a second episode of renal colic. Proteinuria and microscopic haematuria were also noticed, for which he was referred to a nephrologist. On examination, he was a lean young man with no...

Prevention of recurrent calcium nephrolithiasis

Calcium-containing renal calculi are the most common stone type in reported series and recur in 26–53% of patients over a 10 year period. Because of this tendency, interventions aimed at reducing or preventing recurrence are an important strategy for reducing the morbidity associated with stone disease. This guideline uses an evidence-based review of the published literature with the purpose of...